Nextgen mutation detection provides a tool to understand the underlying cause of the four Mi IDEA diseases (Mitochondrial Disease, Intellectual Disability, Epilepsy, and Autism). NextGen DNA Sequence Mediated Personalized Medicine (pMED) defines biochemical weaknesses and can sometimes lead to a transforming personalized diet, supplementation, and/or drug therapy. MEDomics “reads the music of life”. MEDomics integrates NextGen mediated testing with clinical pMED “from A-Z”.
A second PBS TV story illustrates the transforming personalized diet that can sometimes arise from MEDomics testing results (See above FAQ Answer for first PBS story). Personalized diet and/or personalized drug therapy can help our patients with Autism, Mitochondrial Disease, Epilepsy, or Intellectual Disability. Go to the test page of interest for further information. PBS TV Story
If you or your child exhibit symptoms relating to Autism, Mitochondrial Disease (Energy Deficiency), Epilepsy, or Intellectual Disability, is any further testing necessary? To help with possible referrals or to address your specific testing requirements MEDomics can offer a no cost Clinical Genetics MD Consultation to you or, preferably, your physician. For more information please provide us your contact information and a brief clinical and family history to [email protected] For more details on MEDomics testing please click on the “test” tab in the navigationbar above.
We are just at the dawn of a new era of medicine: the 3rd era of Medicine. MEDomics has been recognized for pioneering contributions. About a year ago, PBS TV did a story on MEDomics testing. Filming by a Hollywood producer and director has just completed. The documentary, entitled “The 3rd era of medicine: reading the music of life”, focuses on the personalized medicine of Autism (as a model disease) and on the work and ideas of Steve S Sommer MD PhD Founder and Medical Director of MEDomics. "Reading the music of life" with revolutionary NextGen Sequencing technology can define biochemical weaknesses underlying patient disease and can lead to personalized diet, personalized supplimentation, and/or personalized drug therapy. The six minute PBS story provides a glimpse of MEDomics. PBS TV Story
Currently there is no cure for these diseases, only treatments for symptoms. Thus, treatments and treatment outcomes for each patient or disease vary significantly. Typically a physician will order a test for a patient with a suspected Mi IDEA (Mitochondrial Disease, Intellectual Disability, Epilepsy and/or Autism) Disease and MEDomics will perform the test to search for a deleterious mutation in the DNA of the patient. The power of testing is enhanced by co-sequencing family members. An example of this customized treatment for a person with Mitochondrial Disease may include vitamins such as coenzyme Q10, alpha lipoic acid, L-carnitine, riboflavin, and creatine monohydrate in conjunction with prescribed medicines.
Our goal is to minimize out of pocket costs for patients. Private Insurance (PPO) is generally needed for coverage. We can best help you contacting your insurance provider for details on your coverage, however, most PPO plans pay for testing. In certain circumstances, an insurance denial can be appealed if accompanied by a letter of medical necessity signed by the physician requesting the test. In the minority of cases in which PPO does not pay for testing we will contact you. If you are unable to personally pay for testing, the Mi IDEA Has Love Foundation may be able to provide funding for your tests if you qualify for the program. For more information about the Mi IDEA Has Love Foundation please visit http://miideahaslove.org/
The best way to reach us is to email us at [email protected], if your email is not addressed within 2 business days please call (626) 804-3645.
Test results can be delayed for a variety of reasons: Ordering physicians must sign for the test, provide a test request form, and clearly indicate which kind of test is ordered. Unless we receive all the required information, testing will be delayed and the sample will not be run. There may experimental challenges or other issues. This can delay patient results and these kinds of problems are difficult to anticipate. Laboratories face these obstacles. We have quality control procedures to minimize laboratory errors and ensure the highest quality test results for our patients. Performance and analysis of some patient samples are more time consuming than for other patient samples.
GENE Mutations are the basis of natural selection. They often cause biochemical weaknesses and are expressed in the context of other mutations in the symphony of sometimes redundant physiology. They also often alter disease risk by 3x or less, but there is typically 1-2 nasty mutations of penetrance =20-98% which can change behavioral resonance compasses
The Mi Idea HaS Love Foundation was birthed as a way to provide this sometimes transformational, genetic testing to patients and their families who cannot afford the cost of this critical, cost-effective, cutting edge technology… especially those children with HMO insurance or those with Medicaid/Medicare. The lives of some children and their families can greatly benefit from the financial support provided by this foundation.
Genomology is a transforming medical practice which integrates NextGen sequence-based Clinical Genetics analysis of hundreds to thousands of genes with a referring physician partnership and collaboratively generates an improved therapeutic program for the patient. It involves a sophisticated laboratory component, but differs fundamentally from a diagnostic laboratory in two ways: i) the referred patient DNA (i.e. blood tube) "visits" a physician who practices a specialty of clinical genetics; and ii) as with any referral to a specialist, the Genomologist may specialty manage the patient for a time and then return the patient to the referring physician to provide a diagnostic/therapeutic evaluation & collaboratively enable an appropriate therapeutic program. Referring a patient to a Genomologist is analogous to referring a patient to a surgeon. Both specialists have a highly technical component to their medical practice.
Genostics = Interpretive NextGen-based Genomic Diagnostics. Diagnostics historically provides a few bits of information per test…..or perhaps an image(s) or other moderate amounts of information. Genostics differs dramatically: typically huge amounts of information is managed, analyzed and presented with the high information content permeates Genostics, differentiating it from any conventional diagnostics genostics is the first component of Genomology is an art and a science in the context of islands of knowledge in a sea of ignorance
Sequence of the known structural gene segments, including the protein coding regions of all 20+K known genes: For individuals and their families suffering from a rare and undiagnosed disease, For individuals and their families suffering from a yet undescribed genetic disease, For predicting medically actionable proactive delay or prevention of an impending future disease, For proactive family planning by in vitro fertilization to maximize the health of future children
Commitment to transform Genomology into concrete improvement of the life of patients struggling with a genetic disease. Commitment to minimizing the patient cost of genetic testing in the context of a growing, self-sustaining Genomology firm. If desired, commitment to improving the quality of life for family members
Not typical. Is there therapy and/or prevention of some help identified in most families? Yes Will the biochemical weaknesses defined be more frequently amenable to dramatic therapy as time moves on? Yes. Once the biochemical weakness is defined, physicians can implement novel personalized therapy when it becomes available in the medical literature. Often the islands of biochemical knowledge defined by testing are surrounded by a sea of ignorance. The sea of ignorance will recede with increasing rapidity during the next decade. Notably, a 2013 technology breakthrough in mouse promises to increase the number of transformative therapies because mice models with the identical biochemical weaknesses as the child can be created on a clinical timeframe. Experimentation can identify appropriate personalized diet and personalized drug therapy. The personalized TX compensate for aspects of the underlying biochemical weakness.
*This FAQ is for general knowledge and is not to be used to diagnose or treat disease. Consult your physician regarding all and any treatment decisions.